"One part of it folds into a hairpin structure only in the 4R tau." Within the hairpin, he explained, is a sticky segment called PHF6 that can bind and stack up other tau proteins into large ...

The human body is full of checks and balances that ensure correct growth, development, and function of all our different ...

Scientists have identified a biomarker for Alzheimer's that may help doctors spot the early signs of protein buildup in the ...

Tau protein is a microtubule-associated protein (MAP) known to stabilize the internal structure of neurons, binding to microtubules. These are microscopic tubular structures that support the ...

Scientists from the University of Cologne identified the 1N4R tau isoform as a key contributor to neuronal dysfunction in ...

The buildup of knot-like RNA structures in brain cells may be the key to understanding how uncontrolled protein aggregation drives Alzheimer’s disease.

A research team at the University of Cologne has made a significant breakthrough in understanding the role of the tau protein in Alzheimer's disease.

and tangled tau proteins. In healthy brains, tau binds to—and stabilizes—microtubules, which are hollow structures that play important roles in the structure, function, and development of the ...

and tangled tau proteins. In healthy brains, tau binds to—and stabilizes—microtubules, which are hollow structures that play important roles in the structure, function, and development of the ...

Rather than looking for amyloid-beta plaques like many other Alzheimer's tests, this one hunts for tiny clumps of tau protein, which are more often associated with cognitive decline. The ...

Researchers from the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) have found that tau protein and beta-amyloid – two pathological hallmarks of Alzheimer’s disease – ...

They consist of aggregates of abnormally phosphorylated tau proteins that are altered in conformation. Conformational changes in tau proteins are thought to be the earliest neurobiological changes ...