Alzheimer’s disease, a devastating neurodegenerative disorder, is closely linked to the accumulation of tau protein in the ...

Alzheimer’s disease is increasingly widespread, affecting more than 55 million people worldwide — a figure that’s expected to ...

Phosphorylated tau 217 better detected Alzheimer’s disease pathology across a range of neurodegenerative syndromes compared ...

A new biomarker test can detect early-stage tau protein clumping up to a decade before it appears on brain scans, improving ...

While carrying the dreaded genetic variation that plagued his family members, he still has no symptoms of Alzheimer’s.

New research suggests that consistent aerobic exercise could be a powerful tool in reducing the biological signs associated ...

Alzheimer’s disease — which affects an estimated 7 million Americans — is notoriously difficult to detect, especially in its ...

But they are not specific for Alzheimer’s. Two key biomarkers, amyloid protein, found in plaques, and tau protein, found in tangles, became the targets outside of the brain tissue itself, since their ...

But they are not specific for AD. One of the key biomarkers is the amyloid protein, found in plaques. Another is the tau protein, found in tangles. Once these biomarkers were identified, doctors could ...

increasing tau phosphorylation via MAPK kinase pathways and accelerating tangle formation. Extracellular tau can induce immune responses via a MAPK kinase pathway as well (Figure 4). Taken ...

In contrast, levels of NFTs in the brain correlate better with disease progression. “Once the tau tangles light up on a brain scan,” explains Karikari, “it may be too late to put out the ...