A research team at the University of Cologne has made a significant breakthrough in understanding the role of the tau protein ...

They consist of aggregates of abnormally phosphorylated tau proteins that are altered in conformation. Conformational changes in tau proteins are thought to be the earliest neurobiological changes ...

Rather than looking for amyloid-beta plaques like many other Alzheimer's tests, this one hunts for tiny clumps of tau protein, which are more often associated with cognitive decline. The ...

In Alzheimer's disease and primary 4-repeat tauopathies, large pathological aggregates of the tau protein are found in the brain. For decades, it has been possible to detect tau proteins for ...

"Healthy" tau protein normally helps to provide structural ... RING' that is activated only when two or more TRIM21 proteins cluster together. This means that it only activates and marks its ...

Tau protein and beta-amyloid, key factors in Alzheimer's disease, impact brain circuits differently, with tau affecting memory-related areas and beta-amyloid influencing emotional centers.

The study was focused on analyzing tau, a protein in the brain that plays a key role in Alzheimer's. In people with the neurological disease, tau proteins undergo chemical changes, forming tangled ...

Researchers from the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) have found that tau protein and beta-amyloid – two pathological hallmarks of Alzheimer’s disease – ...

Mar. 30, 2022 — In the course of Alzheimer's disease, two proteins called 'amyloid' and 'tau' accumulate in the brain. A new study with more than 200 participants now provides insights into the ...

This breakthrough was made possible by the development of a novel transgenic mouse model that replicates both tau and beta-amyloid pathologies. “Although both proteins accumulate in the brains ...