Alzheimer’s disease, a devastating neurodegenerative disorder, is closely linked to the accumulation of tau protein in the ...

and tangled tau proteins. In healthy brains, tau binds to—and stabilizes—microtubules, which are hollow structures that play important roles in the structure, function, and development of the ...

SignalChem Biotech, part of Sino Biological, provides a comprehensive range of products and services in biotechnology and life sciences. We provide kinase drug discovery solutions spanning from target ...

Rather than looking for amyloid-beta plaques like many other Alzheimer's tests, this one hunts for tiny clumps of tau protein, which are more often associated with cognitive decline. The ...

June 15, 2021 — A new therapy prompts immune defense cells to swallow misshapen proteins, amyloid beta plaques and tau tangles, whose buildup is known to kill nearby brain cells as part of ...

In healthy individuals, the protein tau stabilizes the tubular building blocks (microtubules) that make up the long projections of the nerve cells. During the development of Alzheimer's disease, tau ...

This breakthrough was made possible by the development of a novel transgenic mouse model that replicates both tau and beta-amyloid pathologies. “Although both proteins accumulate in the brains ...

In 2019, the team engineered protein microtubules to respond instead to gradients of light, which allowed the researchers to shine specific patterns of light on a clump of microtubules and induce ...