Alzheimer’s disease, a devastating neurodegenerative disorder, is closely linked to the accumulation of tau protein in the ...

and tangled tau proteins. In healthy brains, tau binds to—and stabilizes—microtubules, which are hollow structures that play important roles in the structure, function, and development of the ...

and tangled tau proteins. In healthy brains, tau binds to—and stabilizes—microtubules, which are hollow structures that play important roles in the structure, function, and development of the ...

In healthy individuals, the protein tau stabilizes the tubular building blocks (microtubules) that make up the long projections of the nerve cells. During the development of Alzheimer's disease, tau ...

Tau is a protein that is found in cells of the central nervous system and is involved in the assembly and stabilisation of neuronal microtubules – channels used to transport substances to ...

Tau is a protein that is found in cells of the central nervous system and is involved in the assembly and stabilisation of neuronal microtubules – channels used to transport substances to ...

(2) Tau stabilizes microtubules by interacting with tubulin dimers and regulates the cytoskeletal stability and trafficking. Tau is primarily a neuronal protein, although it is also found to a lesser ...

Tau protein (MAPT) is classified as a microtubule-associated ... the formation of which correlates with cognitive impairments in patients. While microtubules are the dominant interaction partners of ...

During neurodegeneration, Tau protein undergoes phosphorylation modifications and conformation changes, which lead to its separation from microtubules and binding to aggregates of varying sizes. One ...