Figure 1. Cartoon displaying the different regulators of TPC2 function. Rab7a enhances TPC2 activity while TMEM63a/b (OCaR1/2) reduce TPC2 activity. ATP blocks TPC2 through mTOR. JPT2 or Lsm12 mediate ...

This manuscript provides a deep mutational scanning of the deaminase domain of human ADAR2 to provide a comprehensive assessment of amino acids that alter editing activity at a specific adenosine ...

Like most plasma membrane proteins, type I interferon (IFN) receptor (IFNAR) traffics from the outer surface to the inner compartments of the cell. Long considered as a passive means to simply control ...

RABGEF1 directs the downstream Rab proteins, RAB5 and RAB7A, to damaged mitochondria, whose associations are further regulated by mitochondrial Rab-GAPs. Furthermore, depletion of RAB7A inhibited ...