In their study, published in the journal Science Translational Medicine, the group found a certain conformation-specific antibody that would bind to tau proteins, placed it inside of a shell that ...

A research team at the University of Cologne has made a significant breakthrough in understanding the role of the tau protein ...

The team found that TTCM2 utilizes a naturally occurring protein in cells known as TRIM21, which functions as an intracellular antibody receptor – helping to mark the antibody-bound tau aggregates.

Tau is a protein that is found in cells of the central ... Biogen and Eisai have already filed for approval of their amyloid-targeting antibody aducanumab, and while some analysts see the evidence ...

In this version, a tau antibody is attached to either a fluorescent donor or acceptor. FRET only occurs when both are close, and because tau monomers can only bind one antibody, they go undetected.

A recent study by the University of Cologne has illuminated a specific tau protein's role in the progression of Alzheimer's ...

Prothena's antibody targets an area within the microtubule binding region (MTBR) of tau, which the Irish biotech reckons is most closely associated with the pathogenic spread of the protein and ...

The concentrations of conformationally altered tau proteins in homogenized dissected areas of the brain were measured by ELISA using two different antibodies specific for tau protein alterations.

“P-Tau can increase three- to seven-fold ... to isolate individual immunocomplexes (consisting of an antibody-bound target protein and fluorescent reporter enzyme), boosting sensitivity at ...

Tau aggregates appear inside synapses from human brain samples with Aβ pathology. The method can be adapted to study other synaptic proteins. As reported in Cell Chemical Biology on January 23, first ...