A research team at the University of Cologne has made a significant breakthrough in understanding the role of the tau protein ...

Tau is a protein that builds up and moves between nerve cells in the brains of people living with Alzheimer’s disease, causing damage. Professor Mudher is using clever genetic manipulation in fruit ...

Rather than looking for amyloid-beta plaques like many other Alzheimer's tests, this one hunts for tiny clumps of tau protein, which are more often associated with cognitive decline. The ...

They consist of aggregates of abnormally phosphorylated tau proteins that are altered in conformation. Conformational changes in tau proteins are thought to be the earliest neurobiological changes ...

This breakthrough was made possible by the development of a novel transgenic mouse model that replicates both tau and beta-amyloid pathologies. “Although both proteins accumulate in the brains ...

The study was focused on analyzing tau, a protein in the brain that plays a key role in Alzheimer's. In people with the neurological disease, tau proteins undergo chemical changes, forming tangled ...