Denali has been working on small-molecule compounds capable of crossing the blood-brain barrier and Biogen has bought a licence to co-develop and co-market compounds known as LRRK2 inhibitors in ...

Their findings point to mutations in the LRRK2 gene as a common element linking both conditions and identify novel genes that are likely to be affected in people experiencing both IBD and PD.

Zhu et al show that LRRK2 kinase promotes invagination of the plasma membrane to create ‘reservoirs’, which dynamically store or release excess membrane. Salmonella can exploit these membrane ...

Zhu et al show that LRRK2 kinase promotes invagination of the plasma membrane to create ‘reservoirs’, which dynamically store or release excess membrane. Salmonella can exploit these membrane ...