Alzheimer’s disease, a devastating neurodegenerative disorder, is closely linked to the accumulation of tau protein in the ...

Scientists have identified a biomarker for Alzheimer's that may help doctors spot the early signs of protein buildup in the ...

The disease is defined in part by two biopathological characteristics: Diffuse and neuritic plaques of Aβ deposited in extracellular spaces Hyperphosphorylated tau protein aggregated into ...

“This study demonstrated the extracellular presence of full-length or almost full-length hyperphosphorylated tau in AD. This suggests that passive immunization with tau antibodies is a viable ...

The microtubule-associated protein tau is commonly implicated in neurodegenerative conditions called tauopathies, such as Alzheimer’s disease, where abnormal and hyperphosphorylated tau aggregates ...

A research team at the University of Cologne has made a significant breakthrough in understanding the role of the tau protein in Alzheimer's disease.

Abundant plaques, especially in the thalamus and subiculum. Aggregated, hyperphosphorylated tau tangles. Neuronal loss, especially of neuropeptide Y (NPY) neurons in the hippocampus and subiculum.

4 Additionally, some areas of the man’s brain had tau tangles—aggregations of hyperphosphorylated tau proteins—that similar to other individuals in this cohort. However, his entorhinal cortex—a brain ...