“Why isn’t my antidepressant working?” is one of the most common (and frustrating) questions I hear. If you’re on treatment but still not feeling much better, here are 3 evidence-based reasons that could explain it 👇 1️⃣ Subtherapeutic dose – Many antidepressants (SSRIs, SNRIs, etc.) need to be titrated up gradually. Starting doses are often just that — a starting point. According to NICE and CKS, you usually need to be on an optimal therapeutic dose for at least 4–6 weeks before deciding if it