P70-S6 Kinase 1 - Wikipedia
Physical exercise activates protein synthesis via phosphorylation (activation) of p70S6K in a pathway that is dependent on mTOR, specifically mTORC1. This has been demonstrated by …
The role of mTOR and phospho-p70S6K in pathogenesis and …
P70 S6 kinase (p70S6K) is activated in a signaling pathway that includes mTOR. P70S6K is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle …
The role of mTOR and phospho-p70S6K in pathogenesis and …
Dec 13, 2009 · mTOR signaling pathway and its downstream serine/threonine kinase p70S6k were frequently activated in human cancers. The dysregulation of the mTOR pathway has …
Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates
Jul 17, 2019 · We demonstrate that disruption of this signaling pathway with mTOR inhibitors, raptor knockdown or p70S6K inhibitors elevated PD-L1 levels in some lung and other cancer …
p70 Ribosomal protein S6 kinase (Rps6kb1): an update
The Rps6kb1 gene encodes the 70 kDa ribosomal protein S6 kinase (p70S6K), which is a serine/threonine kinase regulated by phosphoinositide 3-kinase (PI3K)/mammalian target of …
AKT/mTOR substrate P70S6K is frequently phosphorylated in …
In the present study, we investigated the phosphorylation status of the mTOR substrate p70S6K in preneoplastic and neoplastic gallbladder tissues and evaluated the effect of three mTOR …
Expression and distribution of mTOR, p70S6K, 4E-BP1, and their ...
Using RT-PCR, Western blot analysis, and standard immunofluorescence techniques, we have characterized the expression levels of mTOR, p70S6K, 4E-BP1, and their activated …
Deciphering downstream gene targets of PI3K/mTOR/p70S6K …
Jul 24, 2008 · The 70 kDa ribosomal protein S6 kinase (RPS6KB1), located at 17q23, is amplified and overexpressed in 10–30% of primary breast cancers and breast cancer cell lines. p70S6K …
The AKT/mTOR/P70S6K/4EB-P1 Signaling Pathway Is Activated in …
Nov 16, 2008 · Introduction: The mammalian target of rapamycin (mTOR) is a serine/threonine-specific protein kinase, downstream of the phoshatidylinositol 3-kinase (P13-K/AKT) pathway. …
p70 Ribosomal protein S6 kinase - Journal of Clinical Pathology
The Rps6kb1 gene encodes the 70 kDa ribosomal protein S6 kinase (p70S6K), which is a serine/threonine kinase regulated by phosphoinositide 3-kinase (PI3K)/mammalian target of …