To investigate the novel mechanism mammalian TOR (mTOR)/ signal transducer and activator of transcription 3 (STAT-3) signaling in HGF protective effects against endothelial barrier and …

Jan 5, 2021 · The PI3K/AKT/mTOR signaling pathway is an effective therapeutic target in PTEN-deficient cancer cells, but its inhibitors can induce resistance via feedback activation of …

Mar 5, 2020 · We recently reported that lymphocyte subpopulations are reduced in SDS patients. We have also shown that the mTOR-STAT3 pathway is hyper-activated in SDS myeloid cell …

To assess the activation of mTOR-STAT3 pathway in SDS lymphoid compartment, we determined the phosphorylation of mTOR (S2448) and STAT3 (Y705 and S727) in CD4+ and CD8+ T …

Jan 1, 2015 · STAT3 controls mTOR activity in response to different cytokines. Cytokines activate TYK2 and JAK1, which phosphorylate intracellular receptor domains creating a binding site for …

STAT3/mTOR pathway is activated in mice with kidney injury and addition of STAT3 inhibitor S3I-201 inhibits STAT3/mTOR pathway activation, inhibits autophagy and apoptosis and promotes …

Crosstalk between mTOR and STAT3 signaling has been shown to regulate hypoxia-induced angiogenesis in other diseases. In this study, we determined using OS cell lines if there is a …

Nov 23, 2015 · Our work indicates that targeting STAT3 in parallel to mTORC1 could enhance the anti-angiogenic and anti-tumorigenic properties of mTOR inhibitors that are currently in clinical …

May 1, 2018 · Extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor U0126, mechanistic target of rapamycin (mTOR) inhibitor rapamycin, and signal transducer and activator of …

Sep 17, 2021 · It is known that STAT3 phosphorylation at Ser727 by mechanistic target of rapamycin (mTOR) is necessary for its maximal activation, but the crosstalk between STAT3 …