The tau proteins (abbreviated from tubulin associated unit [5]) form a group of six highly soluble protein isoforms produced by alternative splicing from the gene MAPT (microtubule-associated protein tau).

Dec 23, 2004 · Microtubule-associated proteins (MAPs) of the MAP2/Tau family include the vertebrate proteins MAP2, MAP4, and Tau and homologs in other animals.

May 31, 2023 · Three microtubule-associated proteins (MAPs), MAP2, MAP4, and tau 4,5,6,7,8, which are the most well-studied mammalian-derived MAPs with similar primary structures, promote microtubule ...

Jan 20, 2022 · By combining APEX and AP-MS proteomic approaches, Tau interactome mapping reveals that Tau interactors are modified by neuronal activity and FTD mutations in human iPSC-derived neurons.

The main role of Tau, one of the stabilizing MAPs, is to protect MTs against depolymerization by decreasing the dissociation of tubulin at both MT ends, resulting in an increased growth rate and decreased catastrophe frequency (Murphy et al., 1977; Trinczek et al., 1995).

Tau is the major microtubule associated protein (MAP) of a mature neuron. The other two neuronal MAPs are MAP1 and MAP2. An established function of MAPs is their interaction with tubulin and promotion of its assembly into microtubules and …

Jul 16, 2024 · In this Review, we discuss recent insights into the diverse cellular functions of tau and the pathology of tau inclusions and explore the potential for therapeutic interventions.

Mar 4, 2025 · MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

Mar 31, 2016 · The microtubule associated protein Tau (MAPT) promotes assembly and interaction of microtubules with the cytoskeleton, impinging on axonal transport and synaptic plasticity. Its neuronal expression and intrinsic disorder implicate it in some 30 tauopathies such as Alzheimer’s disease and frontotemporal dementia.

Mar 16, 2019 · In this paper, we compare the longest, 441-residue brain isoform of tau (tau40), and a 467-residue isoform of MAP2, known as MAP2c. For both molecules, we present transient structural motifs revealed by conformational analysis of experimental data obtained for free soluble forms of the proteins.