SV40 large T antigen - Wikipedia
SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant …
SV40 - Wikipedia
SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that is …
SV40 large T antigen targets multiple cellular pathways to elicit ...
Nov 21, 2005 · DNA tumor viruses such as simian virus 40 (SV40) express dominant acting oncoproteins that exert their effects by associating with key cellular targets and altering the …
Cellular transformation by SV40 large T antigen: interaction ... - PubMed
SV40 large T antigen (TAg) is a powerful oncoprotein capable of transforming a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the …
SV40 large T-antigen: dual oncogene - PubMed
One of its gene products, the large tumour antigen (T-ag), is essential for both viral replication and cell transformation. SV40 T-ag can be considered a dual oncogene protein; it is a composite …
T Antigens of Simian Virus 40: Molecular Chaperones for Viral ...
Simian virus 40 (SV40) is a small DNA tumor virus that has been extensively characterized due to its relatively simple genetic organization and the ease with which its genome is manipulated. …
SV40: Cell transformation and tumorigenesis - ScienceDirect
Feb 20, 2009 · Three developments greatly speeded the genetic analysis of SV40, and specifically of large T antigen: DNA sequencing, site-directed mutagenesis, and the ability to …
T antigen and template requirements for SV40 DNA replication in …
A cell-free system for replication of SV40 DNA was used to assess the effect of mutations altering either the SV40 origin of DNA replication or the virus-encoded large tumor (T) antigen. …
SV40 T-antigen uses a DNA shearing mechanism to initiate origin ...
Decades of studies of Simian Virus 40 (SV40), with its double-stranded closed circular DNA genome and its key gene product, the large T-Antigen helicase (T-Ag), provided fundamental …
Viruses unveil the mechanisms of nuclear entry - Nature
Sep 12, 2023 · In two seminal papers, Kalderon et al. reported a short consensus sequence in the large T antigen of simian virus 40 (SV40) that directs its nuclear localization.