MAPK/ERK pathway - Wikipedia
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in …
RAS signaling pathways, mutations and their role in colorectal …
Two of the main cellular pathways in which the RAS protein operates are the mitogen-activated protein kinases (MAPK) and phosphoinositide-3 kinase (PI3K) pathways. In a normal cell, …
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from …
Dec 18, 2023 · RAS/RAF/MAPK can be activate via two pathways: (1) a ligand-dependent pathway, in which ligands, such as growth factors, hormones, or cytokines, physically engage …
RAS Proteins and Their Regulators in Human Disease - PMC
RAS proteins in Drosophila melanogaster and Caenorhabditis elegans regulate pathways that are strikingly similar to the canonical RAS-MAPK pathway in mammalian cells (Lusk et al., 2017).
The Ras Pathway and Cancer: Regulation, Challenges and Therapeutic ...
Jul 8, 2021 · What is the Ras signaling pathway? H-Ras, K-Ras and N-Ras are closely related proteins that are frequently mutated in human cancers. Specifically, they are different isoforms …
The Ras/Raf/MAPK Pathway - Journal of Thoracic Oncology
The Ras/Raf/MAPK pathway is probably the best characterized signal transduction pathway in cell biology. The function of this pathway is to transduce signals from the extracellular milieu to the …
What Do We Mean By "RAS Pathway"? - National Cancer Institute
Oct 22, 2014 · The RAS proteins in turn signal through three alternative pathways to affect many downstream targets including TP53, RB1, and MTOR. Arrows represent activation signals, …
Ras Signaling: Pathways, Mutations, and Tumor Onset
Feb 7, 2025 · Understanding Ras signaling pathways provides insights into how cells communicate and respond to external stimuli. Mutations in Ras genes are among the most …
RAS Signaling Pathway: Mechanisms and Therapeutic Insights
Feb 11, 2025 · Explore the RAS signaling pathway, its molecular mechanisms, and therapeutic insights for targeted cancer treatments. The RAS signaling pathway plays a crucial role in cell …
Targeting RAS signalling pathways in cancer therapy - Nature
The RAS proteins control signalling pathways that are key regulators of several aspects of normal cell growth and malignant transformation.