The ATP-dependent activities of the Rad50 protein are essential for all of its roles in DNA repair and signaling, as mutations of residues involved in ATP binding and hydrolysis exhibit …

Rad50 is a member of the structural maintenance of chromosomes (SMC) family of proteins. [6] Like other SMC proteins, Rad50 contains a long internal coiled-coil domain that folds back on …

Aug 13, 2018 · The rad50-C1G and rad50-C2G mutants retained partial resistance to several DNA damaging agents, including camptothecin, hydroxyurea, and ionizing radiation (IR) (Fig. …

Rad50 resembles the SMC proteins involved in chromosome cohesion and chromatin condensation (Aravind et al. 1999; Strunnikov and Jessberger 1999). SMC proteins all contain …

Mar 4, 2025 · The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex …

Jun 23, 2000 · To clarify the key role of Rad50 in DNA double-strand break repair (DSBR), we biochemically and structurally characterized ATP-bound and ATP-free Rad50 catalytic domain …

Dec 25, 2024 · RAD50 (RAD50 Double Strand Break Repair Protein) is a Protein Coding gene. Diseases associated with RAD50 include Nijmegen Breakage Syndrome-Like Disorder and …

In our study, RAD50 germline mutations were determined using next-generation sequencing in 7657 consecutive unselected breast cancer patients without BRCA1/2 mutations. We also …

RAD50 - Explore an overview of RAD50, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data.

RAD50 homolog (RAD50) is a gene that encodes a protein that functions in double-strand break repair. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions …