Context-dependent regulation of ferroptosis sensitivity - Cell Press
Sep 15, 2022 · RSL3 sensitivity was restored in HT-1080 ACSL4 KO1 cells by re-expressing the long isoform of ACSL4 (Kuch et al., 2014), confirming that effects on ferroptosis were due to …
Emerging mechanisms of lipid peroxidation in regulated cell death …
Nov 26, 2024 · The classical ferroptosis inducers, Erastin and RSL3, can trigger lipid peroxidation by inhibiting system x c-and GPX4. System x c − play a crucial role maintaining the …
A stem cell roadmap of ribosome heterogeneity reveals a function …
Sep 19, 2022 · The Rps6 conditional allele is a gold-standard model for ribosome dysfunction with one of the most severe phenotypes, as even loss of one copy of Rps6 results in early …
RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS
Nov 22, 2018 · Overexpression GPX4 resulted in decreased cell death after RSL3 treatment. Therefore, RSL3 was able to induce ferroptosis on three different CRC cell lines in vitro in a …
Emerging mechanisms and applications of ferroptosis in the …
Oct 1, 2020 · Gemcitabine-resistant pancreatic cancer cells exhibit increased expression of ADP ribosylation factor 6 (ARF6), which can be sensitive to RSL3 [214]. Liu et al. established …
Synergism of non-thermal plasma and low concentration RSL3 …
Feb 12, 2024 · Results: We found the synergism of NTP and low-concentration RSL3 triggered severe mitochondria damage, more cell death and rapid ferroptosis occurrence in vitro and in …
Inactivation of the glutathione peroxidase GPx4 by the ... - PubMed
Ras-selective lethal small molecule 3 (RSL3), a drug candidate prototype for cancer chemotherapy, triggers ferroptosis by inactivating the glutathione peroxidase glutathione …
Matrine Synergistically Promotes Non-Toxic-Dose RLS3 Induced ...
Nov 5, 2024 · The results indicated that MAT + RSL3 significantly downregulated the protein and gene expression of GPX4 and SLC7A11 in MOLM-13 shCtrl cells, and effect reversed by p53 …
RSL3 enhances ROS-mediated cell apoptosis of myelodysplastic
Jul 2, 2024 · In this study, we found that RSL3 inhibited MDS cell proliferation through inducing ROS-dependent apoptosis. RSL3 inhibited Bcl-2 expression and increased caspase 3 and …
Context-dependent regulation of ferroptosis sensitivity
Sep 15, 2022 · RSL3 sensitivity was restored in HT-1080 ACSL4 KO1 cells by re-expressing the long isoform of ACSL4 (Kuch et al., 2014), confirming that effects on ferroptosis were due to …