The ligand-docking approach explores the binding affinity of PFOS …
Dec 20, 2023 · PFOS and PFOA can potentially bind with GPx4, GST, CAT, GR, and SOD1. Such interactions can subvert antioxidant enzyme activities. Disruption of redox homeostasis …
Perfluorooctane sulfonate (PFOS), a novel environmental pollutant ...
Nov 15, 2023 · Protein assays revealed that PFOS can suppress the levels of Nrf2, GPX4 and SLC7A11, trigger oxidative damage and promote the occurrence of ferroptosis [Fig. 1 L-M].
Perfluorooctane sulfonate induces ferroptosis-dependent non …
Jul 15, 2024 · PFOS induced hepatic ferroptosis in vivo and in vitro, as evidenced by the decrease in glutathione peroxidase 4 (GPX4), and the increases in cytosolic iron, acyl-CoA …
Perfluorooctane sulfonate induces ferroptosis-dependent non …
Jul 15, 2024 · PFOS induced hepatic ferroptosis in vivo and in vitro, as evidenced by the decrease in glutathione peroxidase 4 (GPX4), and the increases in cytosolic iron, acyl-CoA …
The Role of Ferroptosis in the Damage of Human Proximal Tubule ...
Jul 29, 2022 · In our study, we found that PFOS could induce the onset of ferroptosis in HK-2 cells with decreased GPx4 expression and elevated ACSL4 and FTH1 expression, which are …
Perfluorooctane Sulfonate Induces Dysfunction of Human …
Aug 28, 2022 · (4) Results: PFOS was shown to cause a decrease in viability and morphological changes of mitochondria, and well as an increase in lipid droplets. The expression of GPX4, …
Expression of ACSL4, GPx4 and FTH1 in HK-2 cells exposed to PFOS …
Perfluorooctane sulfonate (PFOS) is a typical persistent organic pollutant and environmental endocrine disruptor that has been shown to be associated with the development of many …
Perfluorooctane sulfonate causes HK-2 cell injury through …
Nov 19, 2024 · Human proximal tubular epithelial cells (HK-2) were treated with 200 μM PFOS or 1 μM Fer-1. Cell viability, the levels of MDA, GSH, intracellular iron ion, and GPX-4 were …
Perfluorooctane sulfonate (PFOS) and its selected analogs induce ...
Apr 1, 2024 · Our results indicate that only PFOS demonstrated pro-ferroptotic and pro-autophagic potential but observed changes occurred at relatively high exposure. A short-chain …
The Role of Ferroptosis in the Damage of Human Proximal Tubule ...
Jul 29, 2022 · In our study, we found that PFOS could induce the onset of ferroptosis in HK-2 cells with decreased GPx4 expression and elevated ACSL4 and FTH1 expression, which are …