Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenger diacylglycerol. PKC family members phosphorylate a wide …

Protein kinase C-theta (PKCθ) is a member of the novel, Ca2+-independent PKC subfamily, which plays an important and non-redundant role in several aspects of T cell biology. Much …

PKC-θ is a serine/threonine specific protein kinase and its activation depends upon the concentration of diacylglycerol (DAG) and phospholipids (phosphatidylserine). PKC-θ …

Protein kinase C-theta (PKCθ) is a key enzyme in T cell signal transduction, downstream of the activated TCR and the CD28 co-stimulatory receptor.

The novel protein kinase C (PKC) isoform, PKC theta, is selectively expressed in T lymphocytes and is a sine qua non for T cell antigen receptor (TCR)-triggered activation of mature T cells.

Oct 13, 2015 · This review will examine recent knowledge on the role of PKC-θ in T-cell transcriptional responses and how this protein can impact on the function of both Tregs and …

Oct 13, 2015 · Subsequent recruitment of the serine/threonine-specific protein Kinase C-theta (PKC-θ) to the immunological synapse (IS) is instrumental for the formation of …

The serine/threonine-specific protein kinase C-θ (PKC-θ) is a core component of the immunological synapse that was shown in vitro to play a central role in the activation of T cells …

Jun 1, 2007 · Protein kinase C theta (PKCθ) is a member of the novel, Ca 2+-independent PKC subfamily, which plays an important and non-redundant role in several aspects of T cell …

Jun 23, 2009 · Gruber et al. found that protein kinase C-θ (PKC-θ), which is required for normal T cell immune responses, bound to Cbl-b on costimulation of CD28 and that PKC-θ–mediated …