Jan 1, 2018 · Pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) plays key role in glucose metabolism via regulating the activity of pyruvate dehydrogenase complex (PDC). Here, we demonstrated a novel of PDK4 in NASH by regulating hepatic steatosis and insulin signaling pathway in methionine and choline deficient (MCD) diet induced NASH model.

Jan 1, 2018 · In the current study, we identified the role of PDK4 contributed to the pathogenesis of NAFLD and NASH via regulating hepatic lipid and glucose metabolism. Pdk4 deficiency can ameliorated the hepatic steatosis in MCD induced NASH mice via several signaling pathway.

Jan 1, 2018 · Pdk4 deficiency can ameliorated the hepatic steatosis in MCD induced NASH mice via several signaling pathway. This newly identified role of PDK4 provides a novel clue to the pathogenesis of NASH and PDK4 might become a new target for the treatment of …

Feb 24, 2022 · PDK4 plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits (PDHA1 and PDHA2) . PDK4 expression is elevated in human NASH liver specimens, and deletion of PDK4 can alleviate nonalcoholic fatty liver in mice [28, 29]. The specific mechanism of PDK4 in ...

In conclusion, our data indicated that PDK4 potentially contributes to the hepatic steatosis in NASH via regulating several signaling pathway and PDK4 may be a new therapeutic strategy against NAFLD. Low PDK4 expression is associated with lung tumorigenesis.

We now show that pyruvate dehydrogenase kinase 4 (PDK4), plays a role in the regulation of mitochondrial dynamics. PDK4 promotes mitochondrial fission via phosphorylation of Septin 2 (SEPT2) at Ser 218 and thereby triggering the recruitment of DRP1 to the mitochondria.

Jun 4, 2024 · Immunoblotting revealed a significant reduction in the PPARα target gene PDK4 and in PCK1 in mouse NASH samples compared with chow controls (Figure 4 O). To extend these findings to humans, liver samples from patients with obesity were analyzed according to their NAS (liver damage severity).

miR-145a-5p could downregulate the nuclear receptor Nr4a2 to inhibit the expression of NASH-associated genes. We highlight the pathological role of the miR-145a-5p/Nr4a2 axis in steatosis-to-NASH progression.

Pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) plays key role in glucose metabolism via regulating the activity of pyruvate dehydrogenase complex (PDC). Here, we demonstrated a novel of PDK4 in NASH by regulating hepatic steatosis and insulin signaling pathway in methionine and choline deficient (MCD) diet induced NASH model.

PDK4 (pyruvate dehydrogenase kinase 4) regulates pyruvate oxidation through the phosphorylation and inhibition of the pyruvate dehydrogenase complex (PDC). PDC catalyzes the conversion of pyruvate to acetyl-CoA and is an important control …