Apr 1, 2023 · PDK1-catalyzed PDHA pSer 232 contributed to metabolic reprogramming in PMOP. PDHA pSer 232 level highly differs between normal and PMOP-conditioned osteoclasts. PDK1 deficiency and pharmacological PDK1 inhibition suppressed osteoclastogenesis. ICA alleviated PMOP by reversing PDK1-dependent metabolic reprogramming.

Mar 1, 2022 · Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable determinant of different metabolic states in acute myeloid leukemia (AML). PDK1 low AMLs are OXPHOS-driven, are...

Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it further links glycolysis with the tricarboxylic acid cycle and ATP generation.

PDK1 is frequently upregulated in primary nasopharyngeal carcinoma and may serve as a prognostic marker. A new function for PDK1 in metabolic reprogramming, which could be used to indicate the prognosis of Non small cell lung cancer and provide targeted therapeutic strategy for clinical treatment.

PDH kinases (PDK1-4) regulate PDH activity by phosphorylating PDHA1 at three individual serine (Ser, S) residues (S293, S300 and S232) . PDK1 is frequently increased in cancer cells and plays an important role in tilting the energy balance in their favor by enhancing the Warburg effect .

Jan 15, 2018 · Here, we found that genetic and pharmacological inactivation of pyruvate dehydrogenase A1 (PDHA1), a subunit of the pyruvate dehydrogenase complex (PDC), inhibits prostate cancer development...

Dec 25, 2024 · PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease .

Nov 7, 2023 · Research showed that Aβ-resistant nerve cells displayed increased PDK1 expression, enhanced lactate dehydrogenase A (LDHA) activity and reduced mitochondrial ROS, suggesting the potential...

PDK1 is a Ser/Thr kinase that inactivates PDC by phosphorylating at least one of three specific serine residues of PDHA1 (sites 1, 2, and 3 are S293, S300, and S232, respectively), while dephosphorylation of PDHA1 by PDP1 restores PDHA1 and, …

Here we show that PDK1 regulates cardiomyocyte fuel preference by mediating triacylglycerol turnover in differentiated H9c2 myoblasts using lentiviral shRNA to knockdown Pdk1. Somewhat surprisingly, PDK1 loss did not affect overall PDH activity, basal glycolysis, or glucose oxidation revealed by oxygen consumption rate experiments and 13 C 6 ...