In humans, there have been four isozymes of pyruvate dehydrogenase kinase that have been shown to phosphorylate these three sites: PDK1, PDK2, PDK3, and PDK4. PDK4 does not …

In mammals, PDK1-PDK4 are expressed in tissue- or cell-type-specific ways by four different genes, which are responsible for tissue- or cell-specific regulation of PDC. They are mainly …

PDK1 is the largest of the four with 436 residues while PDK2, PDK3 and PDK4 have 407, 406, and 411 residues respectively. The isozymes have different activity and phosphorylation rates …

Oct 30, 2023 · Pyruvate enters the tricarboxylic acid (TCA) cycle through PDH, whereas PDK molecules (PDK1–PDK4) inhibit PDH activity and promotes switch from mitochondrial …

Mar 7, 2024 · By comparing the gene expression in tumors with their corresponding adjacent normal tissues, we uncovered notable discrepancies in the expression levels of PDK1, PDK2, …

Mar 1, 2022 · Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable determinant of different metabolic states in acute myeloid leukemia (AML).

In humans, there have been four isozymes of Pyruvate Dehydrogenase Kinase that have been shown to phosphorylate these three sites: PDK1, PDK2, PDK3, and PDK4. PDK1 is the only …

Jul 4, 2023 · We have demonstrated for the first time that the PDK/PDH axis is associated with vascular inflammation in humans and particularly that the PDK1 isozyme is associated with …

PDK is known to be overexpressed in several cancers and is associated with bad prognosis and therapy resistance. Whereas the expression of PDK1–3 is tissue specific, PDK4 expression is …

The evidence that overexpression of PDK4 in metabolic diseases can result in “off‐target” effects of PDK4; that is, phosphorylation of cytoplasmic and mitochondrial proteins other than the …