Activation of the essential kinase PDK1 by phosphoinositide …
Apr 6, 2022 · In this study, we have elucidated the mechanism of phosphoinositide-driven PDK1 auto-activation. We show that PDK1 trans-autophosphorylation is mediated by a PIP3 …
Hypoxia-induced acetylation of PAK1 enhances autophagy and …
Mar 18, 2020 · Mechanistically, hypoxia induces ELP3-mediated PAK1 acetylation at K420, which suppresses the dimerization of PAK1 and enhances its activity, thereby leading to subsequent …
Mitochondrial ROS-derived PTEN oxidation activates PI3K
Jul 24, 2018 · In this study, we provide evidences that mtROS induce PTEN oxidation to stimulate PI3K/AKT/mTOR signaling pathway and thus promote autophagy, which is required for muscle …
Hypoxia-induced acetylation of PAK1 enhances autophagy and
Mechanistically, hypoxia induces ELP3-mediated PAK1 acetylation at K420, which suppresses the dimerization of PAK1 and enhances its activity, thereby leading to subsequent PAK1 …
Targeting PDK1 with dichloroacetophenone to inhibit acute …
We found that treatment with DAP significantly inhibited cell proliferation, increased apoptosis induction and suppressed autophagy in AML cells in vitro, and inhibited tumor growth in an …
P21-Activated Kinase 1: Emerging biological functions and …
PAK1 regulates autophagy via direct or indirect regulation. Acetylation of PAK1 could phosphorylate ATG5 to inhibit its ubiquitination-dependent degradation to promote autophagy. …
Direct Induction of Autophagy by Atg1 Inhibits Cell Growth and …
Our results reveal a central role for Atg1 in mounting a coordinated autophagic response and demonstrate that autophagy has the capacity to induce cell death. Furthermore, this work …
Dioscin ameliorates doxorubicin‐induced heart failure via …
Aug 14, 2023 · Besides, the effects of Dioscin on Dox-stimulated HL-1 cell apoptosis, oxidative stress, and autophagy-associated proteins Beclin1 and Atg5 were offset after co-incubation …
Desialylation of Atg5 by sialidase (Neu2) enhances …
Feb 1, 2021 · Atg5, a crucial protein for autophagosome formation, exhibited enhanced association with overexpressed Neu2 leading to its desialylation. Desialylated Atg5 now …
A Novel PDK1/MEK Dual Inhibitor Induces Cytoprotective
Feb 6, 2023 · In a preliminary study, we synthesized a series of new PDK1/MEK dual inhibitors. Antitumor activity screening showed that Compound YZT exerts a strong inhibitory action in …