p16/Ki-67 dual-staining cytology is of great significance in screening and triaging of cervical cancer and precancerous lesions. It provides a good risk marker for the stratification of HPV …

Oct 11, 2018 · It measures the presence of two specific proteins, p16 and Ki-67, in a sample of cervical cells. The expression of p16 is strongly linked with HPV infection, and Ki-67 is used as …

p16 and Ki-67 immunohistochemistry can be used as an ancillary method for the diagnosis of squamous intraepithelial lesion (SIL) versus atrophic change and atypical squamous metaplasia.

P16/Ki-67 dual staining enhances the detection of precancerous lesions in HPV-positive individuals, improving risk stratification and reducing unnecessary procedures. While it offers …

Dual staining of cytology specimens detects a marker of HPV-related oncogene activity (p16, a tumor suppressor protein) and a marker of cell proliferation (Ki-67) that, when detected …

Triage with p16/Ki-67 dual-stain (DS) testing has shown high sensitivity and specificity for detection of cervical precancers; however, longitudinal studies are needed to determine the …

Jun 2, 2019 · There is increasing evidence that p16/Ki-67 dual-staining cytology can be used as an alternative biomarker, showing overall high sensitivity and specificity for identifying high …

Jul 30, 2012 · We show that p16/Ki-67 does best at detecting precancers with the highest risk of progression to cancer, namely, those related to HPV16 among women 30 years and older. …

Feb 19, 2024 · This review explores the application of p16/Ki-67 dual-staining cytology for cervical cancer screening. This advanced immunocytochemical method allows for simultaneously …

When combined with liquid-based (LB) cytology, DS demonstrated superior sensitivity and specificity compared to other screening strategies. This review suggests that p16 and Ki-67 …