OX40L is the ligand for OX40 (also known as CD134 or TNFRSF4) and is stably expressed on many antigen-presenting cells such as DC2s (a subtype of dendritic cells), [1] macrophages, …

The ligand of OX40 (OX40L, CD252, TNFSF4) belongs to the TNF superfamily and was first identified as gp34 a protein on HTLV-I transformed cells (12, 13) and later found to bind OX40 …

Oxalate ion is a bidentate ligand even though it contains four O atoms which have lone pairs of electrons. In this complex, two oxalate ions are bonded to the Ni atom. The coordination …

OX40 (CD134) and its binding partner OX40-Ligand (OX40L) represent members of the TNFR and TNF superfamilies that appear to be crucial to many types of immune reaction mediated …

Bis (oxazoline) ligands (often abbreviated BOX ligands) are a class of privileged chiral ligands containing two oxazoline rings. They are typically C 2 ‑symmetric and exist in a wide variety of …

When OX40 on activated T cells binds OX40L on antigen-presenting cells, T-cell activation and immune stimulation are initiated via enhanced T-cell survival, proliferation and cytotoxicity, …

Dec 15, 1998 · Ox-40 and Ox-40 ligand (Ox-40L) are thought to be involved in T cell-APC interactions. However, their exact role in T cell responses is undefined. Using fibroblast …

Dec 15, 1998 · APCs with Ox-40L promoted partial activation of naive T cells with some IL-2 secretion, but were unable to enhance proliferation, unlike those with B7-1. APCs …

The single identified ligand for OX40 is OX40L (TNFSF4), which is predominantly expressed on APCs. The OX40-OX40L receptor-ligand pair delivers a late co-stimulatory signal to T cells …

One of the most promising costimulatory targets is OX40 and its ligand, OX40L. OX40L is directly mediated by thymic stromal lymphopoietin (TSLP), which is produced by epithelial cells, 5 …