Feb 21, 2020 · Here, we established an ATII-specific KrasG12D/+ / Men1−/− driven genetically engineered mouse model and show that deficiency of menin results in the accumulation of …

Thus, we have established a mouse model (Men1 L/L /RIP2-CreER) to study early events in the development of pancreatic β-cell NETs. Keywords: multiple endocrine neoplasia, pancreatic …

Jan 30, 2001 · To examine the role of MEN1 in tumor formation, a mouse model was generated through homologous recombination of the mouse homolog Men1. Homozygous mice die in …

Mouse models can serve as effective experimental surrogates of autosomal dominant human genetic disorders, such as MEN1. Also, mouse models with tumors of MEN1 from …

Nov 12, 1998 · The gene responsible for multiple endocrine neoplasia type 1 (MEN1), a heritable predisposition to endocrine tumours in man, has recently been identified. Here we have …

Sep 3, 2024 · We found that MEN1 knockout resulted in increased tumor growth in immunodeficient mice but decreased growth in immunocompetent mice, revealing both TME …

Jun 3, 2019 · We propose that Pten loss combined with Men1 loss accelerates tumorigenesis. To test this, we developed two genetically engineered mouse models (GEMMs)—MPR …

In this review, we present the currently available data concerning the generation and characterization of Men1 mutant mouse models in connection with MEN1 syndrome.

View mouse Men1 Chr19:6385009-6390921 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

Apr 18, 2017 · To generate a temporally controlled conditional mouse model, we crossbred mice with the MEN1 gene floxed by LoxP sites ( Men1L/L ), and mice expressing tamoxifen …