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Prospective studies in relatives of patients with type 1 diabetes have shown that development of 1 or more islet autoantibodies (including IA-2 antibody) provides an early marker of progression to type 1 diabetes.

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A value greater than or equal to 7.5 Units/mL is considered positive for IA-2 autoantibody. This assay is intended for the quantitative determination of autoantibodies to Islet Antigen-2 (IA-2) in human serum. Results should be interpreted within the context of clinical symptoms.

Autoantibodies to IA 2, a tyrosine phosphatase-like protein, are found in 50% to 75% of type 1 diabetics at and prior to disease onset. These autoantibodies are generally more prevalent in younger onset patients.

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IA2 stands for Insulinoma-Associated Protein 2, which is a type of protein found in the pancreas. IA2 antibodies are autoantibodies directed against this protein. These antibodies are significant markers in identifying autoimmune diabetes, particularly Type 1 diabetes mellitus.

Autoantibodies to IA2, a tyrosine phosphatase-like protein, are found in 50% to 75% of type 1 diabetics at and prior to disease onset. These autoantibodies are generally more prevalent in younger onset patients.

Prediction of Type 1 Diabetes: Autoantibodies against IA-2 (IA-2A) in an asymptomatic individual places the subject at increased risk for the development of type 1 diabetes. Methodology: Radioimmunoassay

Islet cell antigen 2 (IA2) testing is available individually (this test) and with glutamic acid decarboxylase 65-kilodalton isoform (GAD65), insulin, and zinc transporter 8 (ZnT8) antibodies as a part of DBS1 / Diabetes Mellitus Type 1 Evaluation, Serum.