Hippo signaling pathway - Wikipedia
The Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway, is a signaling pathway that controls organ size in animals through the regulation of cell proliferation …
Hippo–YAP/TAZ signalling in organ regeneration and regenerative ...
Dec 13, 2018 · Here, we review the role of Hippo signalling in animal regeneration, examine the promises and risks of YAP/TAZ activation for regenerative medicine and discuss strategies to …
The Hippo signalling pathway and its implications in human …
Nov 8, 2022 · Here, we review the key components and upstream signals of the Hippo pathway, as well as the critical physiological functions controlled by the Hippo pathway. Additionally, …
YAP and TAZ: a nexus for Hippo signaling and beyond - PMC
Here we review the regulatory mechanisms of the Hippo pathway and discuss the function of Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ), the …
The Hippo-YAP signaling pathway and contact inhibition of …
The Hippo-YAP pathway mediates the control of cell proliferation by contact inhibition as well as other attributes of the physical state of cells in tissues. Several mechanisms sense the spatial …
YAP/TAZ upstream signals and downstream responses
Jul 26, 2018 · We review how the transcriptional regulators YAP and TAZ integrate mechanical cues with the response to soluble signals and metabolic pathways to control multiple aspects …
The biology of YAP/TAZ: hippo signaling and beyond - PubMed
YAP/TAZ are well known for being the effectors of the Hippo signaling cascade, and mouse mutants in Hippo pathway components display remarkable phenotypes of organ overgrowth, …
The Hippo Pathway and YAP Signaling: Emerging Concepts in …
The Hippo pathway is a serine/threonine kinase module that phosphorylates YAP on serine residues, especially serine 127, the consequence of which is sequestration of YAP in the …
The Hippo pathway: Organ size control and beyond
Mar 1, 2025 · Physiological functions of the Hippo pathway. The YAP/TAZ-TEAD transcriptional complex integrates diverse upstream signals to regulate fundamental cellular processes, …
The Hippo-YAP pathway in various cardiovascular diseases: …
Aug 18, 2022 · The Hippo-YAP pathway regulate the inflammation response in heart failure and cardiomyopathy. YAP increases the accumulation of inflammatory cells and impairs cardiac …