Changes in extracellular matrix (ECM) composition and structure appear to be important pathophysiological mechanisms in HFpEF. ECM expansion secondary to collagen …

While the ECM-based changes are likely to be the main factor in the advanced stages of the disease, the cardiomyocyte-based changes occur in the early stages of HFpEF (Franssen and …

Mar 19, 2024 · Heart failure with preserved ejection fraction (HFpEF), previously known as diastolic heart failure, is currently defined as a left ventricular ejection fraction of ≥50% with …

Heart failure with preserved ejection fraction (HFpEF) portrays a significant burden in terms of prevalence, morbidity, mortality, and health care costs. There is a lack of consensus on the …

Jun 20, 2014 · Schematic of myocardial abnormalities revealed in human heart failure with a preserved ejection fraction (HFpEF). The left side shows components of the β-adrenergic (β …

Oct 24, 2017 · Collagen content in myocardial tissue from patients with HFpEF, and CMR-derived myocardial ECM volume in patients with HFpEF, are associated with echocardiographic …

Fibrosis ultimately results in the accumulation of extracellular matrix (ECM) at the site of injury and the production of a “scar”. Short‐term fibrotic processes can be adaptive, but persistent …

Mar 10, 2025 · HFpEF was defined until recently as a clinical syndrome with symptoms and/or signs of HF and a left ventricular (LV) ejection fraction (EF) measurement of ≥ 45%. ...

Myocardial fibrosis, characterized by accumulation of collagen-rich ECM, is a distinct disease mechanism in heart failure with preserved ejection fraction (HFpEF). Direct, specific …

Apr 19, 2023 · Several studies have reported associations between elevated inflammatory biomarkers and incident HFpEF, prevalent HFpEF severity, and outcomes. 61-64 The …