Glutathione peroxidase 4 - Wikipedia
Glutathione peroxidase 4, also known as GPX4, is an enzyme that in humans is encoded by the GPX4 gene. [5] GPX4 is a phospholipid hydroperoxidase that protects cells against membrane …
GPX4 in cell death, autophagy, and disease - PMC - PubMed …
GPX4 inhibitors are classified into two main types: GPX4 activity inhibitors and GPX4 protein degraders. RSL3, ML210, ML162, and FIN56 are among the most used GPX4 inhibitors to …
The Selenoprotein Glutathione Peroxidase 4: From Molecular …
Recently, GPX4 was discovered to be involved in a rare neonatal lethal disorder called Sedaghatian-type spondylometaphyseal dysplasia (SSMD). In several cases of SSMD …
GPX4 in cell death, autophagy, and disease - Taylor & Francis Online
gpx4 global knockout mice exhibit embryonic lethality, whereas gpx4-related conditional knockout mice also display selective developmental defects, increased cell death, or disease …
Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis
Dec 18, 2023 · We further discover OTU deubiquitinase 5 (OTUD5) as a GPX4-binding protein that confers ferroptosis resistance by stabilizing GPX4.
HCMV infection downregulates GPX4 and stimulates lipid …
Jan 7, 2025 · HCMV-mediated GPX4 downregulation could be a side effect of other processes that are advantageous for virus replication or propagation. Alternatively, GPX4 downregulation …
Inhibition of GPX4 enhances CDK4/6 inhibitor and endocrine
Nov 5, 2024 · Our data demonstrate that CDK4/6 and ER inhibition creates vulnerability to ferroptosis induction, that could be exploited through combination with GPX4 inhibitors, to …
GPX4-independent ferroptosis—a new strategy in disease’s therapy
Oct 30, 2022 · The study of GPX4-independent ferroptosis pathways can better target ferroptosis to prevent and treat various diseases.
Mutations in the enzyme glutathione peroxidase 4 cause
Our identification of truncating mutations in GPX4 in two families affected with SSMD supports the pathogenic role of mutated GPX4 in this very rare disease. GPX4 is a member of the …
Glutathione peroxidase 4 prevents necroptosis in mouse …
Jan 1, 2016 · Recently, it was shown that the high vitamin E content typically present in regular animal chow (55-135 mg/kg) can partially compensate for Gpx4 loss in endothelial cells in …