Oct 30, 2003 · We demonstrate that p53 and ets-1 coregulate TXSA in an antagonistic and inter-related manner, with ets-1 being a potent transcriptional activator and p53 inhibiting ets-1 …

We investigated the mechanism of mutant p53 binding by mapping the human genomic binding sites for p53 R273H using ChIP-Seq and showed them to localize to ETS DNA sequence …

Mar 21, 1996 · In situ hybridization analyses of ETS1 and ETS2 expression during mouse embryogenesis, have shown a pattern similar to that of p53 gene expression. Significantly, we …

Here, we uncover that sensitivity of cancer cells against ETS factor blockade by the small molecule inhibitor YK-4-279 is strongly promoted by p53 loss in a MAPK-driven background. …

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of …

Apr 28, 2017 · ETS2 functions with p53-GOF mutants to epigenetically regulate super-enhancers. ETS factors function in both cell-autonomous and non-cell-autonomous manners in the tumour …

Oct 19, 2001 · Biochemical analysis revealed that Ets-1 interacted exclusively with mutant p53s in vivo but not with wild-type p53. These findings are the first to demonstrate the induction of …

Jan 30, 2014 · We investigated the mechanism of mutant p53 binding by mapping the human genomic binding sites for p53 R273H using ChIP-Seq and showed them to localize to ETS …

Kim E, Günther W, Yoshizato K, Meissner H, Zapf S, Nüsing RM, et al. Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the …

Jan 9, 2009 · It is shown that mouse ES cells lacking Ets1 are deficient in their ability to undergo UV‐induced apoptosis, similar to p53 null ES cells, and suggests that Ets 1 may contribute to …