C57BL/6, often referred to as "C57 black 6", "B6", "C57" or "black 6", is a common inbred strain of laboratory mouse. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease.

C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis.

Jun 22, 2016 · Since C.C. Little (the founder of The Jackson Laboratory) initially generated the C57BL inbred strain in the 1920’s-1930’s, the inbred substrain C57BL/6 became the most frequently used mouse strain in biomedical research.

C57BL/6J is the most widely used inbred mouse strain and the first to have its genome sequenced. C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss.

In this retrospective study, we screened data from more than 12,000 mice phenotyped in the German Mouse Clinic from January 2006 through June 2014 and selected animals with the genetic background of C57BL/6J, C57BL/6N, or C3HeB/FeJ. In addition, we distinguished between the C57BL/6NTac substrain and C57BL/6N mice received from other vendors.

The C57BL/6 (B6) mouse strain is the most widely used strain in biomedical research, with nearly 25,000 articles on Pubmed documenting its use. Nearly half of these articles cite the use of C57BL/6J (B6/J), the original B6 strain from the Jackson Laboratory (JAX) from which all other B6 substrains were derived.

Sep 12, 2017 · C57BL/6NTac mice are prone to developing diet-induced obesity and insulin resistance when fed a high fat diet. Increased adiposity when maintained on an 11% fat diet would not be surprising. Taconic's standard chow is the NIH 31M formula .

C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss (this strain is homozygous for Cdh23 ahl). They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis.

The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been incorporated into many genetic reference populations. More recently large initiatives such as the International Knockout Mouse Consortium (IKMC) are using the ...

The Black 6 (B6) mouse model is one of the most reliable and consistent inbred strains used in biomedical research. Known for its uniform genetic makeup, the C57BL/6 strain is ideal for researchers who require highly reproducible results across experiments.