Akt–RSK–S6 Kinase Signaling Networks Activated by ... - Science
Aug 24, 2010 · Our approach provides a new view of RTK and Akt–RSK–S6 kinase signaling, revealing previously unidentified Akt–RSK–S6 kinase substrates that merit further …
mTOR, S6 and AKT expression in relation to proliferation and ... - PubMed
Background: The mammalian target of rapamycin (mTOR) controls cell growth through protein synthesis regulation. It can be activated by protein kinase B (AKT) or through ribosomal S6 …
Akt-RSK-S6-kinase Signaling Networks Activated by Oncogenic …
A focused view of Akt-RSK-p70 S6 Kinase Signaling. This study provides a large-scale identification and analysis of substrates phosphorylated by the Akt, RSK, and S6 family of …
S6K1-mediated phosphorylation of PDK1 impairs AKT kinase
Mar 22, 2022 · Here we report that ribosomal protein S6 kinase beta 1 (S6K1), a member of AGC kinases and downstream target of mechanistic target of rapamycin complex 1 (mTORC1), …
Beyond controlling cell size: functional analyses of S6K in ... - Nature
Jul 25, 2022 · As a substrate and major effector of the mammalian target of rapamycin complex 1 (mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been …
Constitutively active Akt1 expression in mouse pancreas requires S6 ...
Nov 3, 2008 · Here, we set out to study the interplay between Akt and S6K in the regulation of pancreatic β cell growth and function. In addition, we address whether the constitutive …
Balancing Akt with S6K - PMC - National Center for Biotechnology ...
Nov 8, 2004 · Akt-directed phosphorylation of tuberin relieves its inhibition of TOR, via activation of the small G protein Rheb (not depicted). TOR activation by this pathway requires the …
S6 Kinase2 Promotes Breast Cancer Cell Survival via Akt
Apr 1, 2011 · In the present study, we have examined the effects of S6K2 on Akt activation and cell survival. Silencing of S6K1 caused a modest decrease whereas knockdown of S6K2 …
Robust anti-myeloma effect of TAS0612, an RSK/AKT/S6K
Oct 22, 2024 · In this study, we revealed that the triple targeting of RSK, AKT, and S6K by TAS0612 leads to the modulation of various pathophysiologically and clinically important …
Balancing Akt with S6K: implications for both metabolic ... - PubMed
Nov 8, 2004 · Proper regulation of the phosphoinositide 3-kinase-Akt pathway is critical for the prevention of both insulin resistance and tumorigenesis.