Sep 10, 2019 · AKT, also named protein kinase B (PKB), is a primary mediator of the PI3K signaling pathway; and ERK at the end of MAPK signaling is the unique substrate and downstream effector of mitogen-activated protein/extracellular signal-regulated kinase (MEK).

Analyzing the crosstalk mechanisms of the RAS-ERK and PI3K/AKT signaling, the authors found that activation of PI3K/AKT after RAS-ERK pathway inhibition required β1 integrin, myosin light chain kinase (MLCK), and myosin IIA.

This review has emphasized on involvement of Akt/Erk cascade in the neurodegeneration. Akt has been reported to regulate neuronal toxicity through its various substrates like FOXos, GSK3β, and caspase-9 etc. Akt is also involved with PI3K in …

To examine the correlation between ERK and Akt activity in more detail, we calculated the integrated response (AUC) for ERK and Akt in every cell for the different treatments. By plotting the ERK versus Akt activity, the relationship between both activities can be visualized.

Jun 23, 2020 · In this Review, we discuss the current understanding of this important class of kinases. We begin with a brief overview of the structure, regulation, substrate recognition and subcellular...

Previous studies have shown that, in part, Akt and ERK promote mTORC1 signaling through phosphorylation of a GTPase activator protein (GAP), referred to as tuberous sclerosis complex 2 (TSC2), that acts as an upstream inhibitor of mTORC1.

It is historically well known that signaling by the PI3K-AKT and MEK1/2-ERK1/2 pathways in a cell type-dependent fashion can collaborate to maintain cell viability. 1-3 Signaling pathways can also crosstalk with each other wherein one pathway can signal to either enhance or suppress signaling by another. 4 Signaling by the ERK1/2 pathway can ...

Jun 4, 2024 · Understanding the dynamics of intracellular signaling pathways, such as ERK1/2 (ERK) and Akt1/2 (Akt), in the context of cell fate decisions is important for advancing our knowledge of cellular...

Sep 10, 2019 · Dual inhibitors of AKT and ERK yield clinical benefits in targeted cancer therapy. Phosphatidylinositol 3-kinase (PI3K)/AKT pathway regulates cell growth, proliferation, survival, mobility and invasion.

Here, we focus on recent findings on the convergent regulation of downstream functions by AKT and ERK pathways and discuss the biologic and therapeutic relevance of the pathway convergence in cancer. proliferation, The PI3K/AKT extracellular transduction and RAS/RAF/MEK/ERK two stimuli.