mTORC2 controls cell survival and proliferation mainly through phosphorylation of several members of the AGC (PKA/PKG/PKC) protein kinase family. mTORC2 regulates actin cytoskeleton through PKCα [33] but is able to phosphorylate other members of the PKC family that have various regulatory functions in cell migration and cytoskeletal remodeling.

Jan 5, 2023 · Here, we review recent advances that describe a role for mTORC2 in this catabolic process, and propose that mTORC2 could be a potential clinical target for the treatment of autophagy-related diseases.

Sep 4, 2020 · Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2.

Oct 2, 2023 · The mTORC2 is a complex of mTOR, DEPTOR, mSIN1, Rictor, Protor, and mLST8 to regulate cell survival, proliferation, migration, and cytoskeleton remodeling. Created with BioRender.com

mTORC2 is a negative regulator of macroautophagy and chaperone‐mediated autophagy via its ability to signal to various downstream effectors shown to modulate autophagy in mammals including AKT, PKC, SGK‐1, and FOXO transcription factors.

mTORC2 controls glycolysis via Akt-dependent and -independent mechanisms. Akt has long been studied as a central regulator of glucose metabolism. It modulates glycolytic enzymes such as hexokinase and PFK2 as well as the glucose transporter GLUT1 (262, 263).

The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is known about the regulation and functions of mTORC1 due to availability of a ...

Jul 12, 2021 · The mechanistic target of rapamycin (mTOR) has gathered significant attention as a ubiquitously expressed multimeric kinase with key implications for cell growth, proliferation, and survival. This kinase forms the central core of two distinct complexes, mTORC1 and mTORC2, which share the ability of …

Jul 1, 2021 · A central signaling molecule that integrates growth with metabolism is the mechanistic target of rapamycin (mTOR). mTOR is a protein kinase that responds to levels of nutrients and growth signals. mTOR forms two protein complexes, mTORC1, which is sensitive to rapamycin, and mTORC2, which is not directly inhibited by this drug.

1 day ago · The mechanistic target of rapamycin complex 2 (mTORC2) signaling pathway, which regulates cell growth and migration, exhibits oncogenic function in colorectal cancer (CRC). mTORC2 signaling is primarily activated by a complex assembly of mTOR, RICTOR, SIN1, and mLST8, but how dysregulation of this mechanism contributes to its oncogenic function remains elusive. Here, we show that the Src-Like ...