Multi-mechanisms are involved in reactive oxygen species
The mammalian target of rapamycin complex 1(mTORC1) integrates diverse signals to control cell growth, proliferation, survival, and metabolism. Role of reactive oxygen species (ROS) on …
- Author: Ming Li, Li Zhao, Jun Liu, Anling Liu, Chunhong Jia, Dongzhu Ma, Yu Jiang, Xiaochun Bai
- Publish Year: 2010
See results only from pubmed.ncbi.nlm.nih.govRegulation of innate immun…
Activation of mTORC1 is required for human and mouse mast cell survival …
Regulation and metabolic fu…
In GCN5L1-depleted cardiac cells, restoring rictor acetylation mitigates the …
Mechanistic Target of Rapam…
Blockade of ROS signaling with Tempol restores endothelial function in vascular …
mTORC1-dependent increas…
Our results demonstrate that ROS and leptin require mTORC1 pathway activity …
ATM signals to TSC2 in the c…
Our results identify a cytoplasmic pathway for ROS-induced ATM activation of …
Mitochondrial ROS-derived PTEN oxidation activates …
Jul 24, 2018 · Mitochondrial ROS-induced mTOR activation phosphorylates ULK1 at serine 317 for autophagy initiation and stimulates expression of autophagy …
- Author: Jin-Hwan Kim, Tae Gyu Choi, Seolhui Park, Hyeong Rok Yun, Ngoc Ngo Yen Nguyen, Yong Hwa Jo, Miran Ja...
- Publish Year: 2018
Regulation of innate immune cell function by mTOR
Activation of mTORC1 is required for human and mouse mast cell survival and the expression of IL-8 and TNF after FcεRI stimulation 145, 148. mTORC2 activity also contributes to PGE 2-mediated chemotaxis, CCL2 expression, and …
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Oxidative stress downstream of mTORC1 but not AKT …
Dec 19, 2016 · We found that ROS were produced in a mammalian target of rapamycin complex 1 (mTORC1)-dependent, but AKT-independent, manner …
- Author: M Dermit, P Casado, V Rajeeve, E H Wilkes, D E Foxler, H Campbell, S Critchlow, T V Sharp, J G Gribb...
- Publish Year: 2017
Regulation and metabolic functions of mTORC1 and …
In GCN5L1-depleted cardiac cells, restoring rictor acetylation mitigates the generation of mitochondrial reactive oxygen species (ROS) and increases cell survival in response to hypoxia and reoxygenation. Hence, these findings so …
Mechanistic Target of Rapamycin Complex 1 Signaling Modulates …
Blockade of ROS signaling with Tempol restores endothelial function in vascular rings with increased mTORC1 activity indicating a crucial interaction between mTORC1 and ROS …
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mTORC1-dependent increase in oxidative metabolism in POMC …
Our results demonstrate that ROS and leptin require mTORC1 pathway activity in POMC neurons to increase oxidant levels in POMC neurons and consequently decrease food intake.
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in …
Mar 2, 2010 · Our results identify a cytoplasmic pathway for ROS-induced ATM activation of TSC2 to regulate mTORC1 signaling and autophagy, identifying an integration node for the …
αKG-induced oxidative stress and mTOR inhibition as a …
5 days ago · Concurrently, consistent downregulation of the MTORC1_SIGNALING pathway suggests impaired cell growth and survival (Fig. 2G, H). These findings collectively propose …
Multi-mechanisms are involved in reactive oxygen species …
Oct 1, 2010 · We demonstrate that low doses ROS exposure stimulate mTORC1 while high concentrations or long-term ROS treatment decrease mTORC1 activity in vivo and in a variety …