To investigate the novel mechanism mammalian TOR (mTOR)/ signal transducer and activator of transcription 3 (STAT-3) signaling in HGF protective effects against endothelial barrier and apoptosis, we used recombinant mouse HGF in endothelial cells.

Jan 5, 2021 · The PI3K/AKT/mTOR signaling pathway is an effective therapeutic target in PTEN-deficient cancer cells, but its inhibitors can induce resistance via feedback activation of STAT3, which...

Mar 5, 2020 · We recently reported that lymphocyte subpopulations are reduced in SDS patients. We have also shown that the mTOR-STAT3 pathway is hyper-activated in SDS myeloid cell populations. Here we show that mTOR-STAT3 signaling is markedly upregulated in the lymphoid compartment of SDS patients.

To assess the activation of mTOR-STAT3 pathway in SDS lymphoid compartment, we determined the phosphorylation of mTOR (S2448) and STAT3 (Y705 and S727) in CD4+ and CD8+ T cells, DN T cells, γδT cells, and NK cells isolated from peripheral blood from seven patients with SDS.

Jan 1, 2015 · STAT3 controls mTOR activity in response to different cytokines. Cytokines activate TYK2 and JAK1, which phosphorylate intracellular receptor domains creating a binding site for PI3K. STAT3 can act as an adapter protein linking PI3K to cytokine receptors, resulting in activation of AKT/mTOR pathways downstream of PI3K (reviewed in [84] ).

STAT3/mTOR pathway is activated in mice with kidney injury and addition of STAT3 inhibitor S3I-201 inhibits STAT3/mTOR pathway activation, inhibits autophagy and apoptosis and promotes cell proliferation.

Crosstalk between mTOR and STAT3 signaling has been shown to regulate hypoxia-induced angiogenesis in other diseases. In this study, we determined using OS cell lines if there is a crosstalk between these two pathways and how that impacts sensitivity to …

Nov 23, 2015 · Our work indicates that targeting STAT3 in parallel to mTORC1 could enhance the anti-angiogenic and anti-tumorigenic properties of mTOR inhibitors that are currently in clinical use [ 3 ]. Through RTKs, growth factors (IGF-1, Insulin, and PDGF) and cytokines (Interleukins) activate mTORC1 and STAT3, which are both upstream of HIF-1α.

May 1, 2018 · Extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor U0126, mechanistic target of rapamycin (mTOR) inhibitor rapamycin, and signal transducer and activator of transcription 3 (Stat3) inhibitor S31-201 were used to test the role of ERK1/2/mTOR/Stat3 signaling pathway in regulating autophagy.

Sep 17, 2021 · It is known that STAT3 phosphorylation at Ser727 by mechanistic target of rapamycin (mTOR) is necessary for its maximal activation, but the crosstalk between STAT3 and mTOR signaling in cisplatin resistance remains elusive.