
Sarcomere - Wikipedia
A sarcomere is defined as the segment between two neighbouring Z-lines (or Z-discs). In electron micrographs of cross-striated muscle, the Z-line (from the German "zwischen" meaning between ) appears in between the I-bands as a dark line that anchors the actin myofilaments.
The vertebrate muscle Z-disc: sarcomere anchor for structure and ...
The Z-disc, appearing as a fine dense line forming sarcomere boundaries in striated muscles, when studied in detail reveals crosslinked filament arrays that transmit tension and house myriads of proteins with diverse functions.
Z disc Definition and Examples - Biology Online Dictionary
Jun 17, 2022 · The Z disc is where the actin filaments attach to and thereby serves as the anchoring point of actin filaments in a sarcomere. Synonym(s): intermediate disk (disc)
The Sarcomeric Z-Disc and Z-Discopathies - PMC - PubMed …
Z-discs (Z-disk, Z-line, Z-band) delineate the lateral borders of sarcomeres and are the smallest functional units in striated muscle. The core of a Z-disc consists of actin filaments coming from adjacent sarcomeres which are crosslinked by α actinin molecules .
Sarcomere Structure: Z-Line to H-Zone Explained
Oct 26, 2024 · The Z-line, also known as the Z-disc, serves as a boundary within the sarcomere, marking the ends of each unit. This structure is primarily composed of a network of proteins that anchor the actin filaments, providing structural integrity and alignment.
Z disk - Definition - Glossary - PhysiologyWeb
Jan 8, 2015 · The Z disk (or Z line) defines the boundaries of a muscle sarcomere. Two adjacent Z disks along the myofibril mark the boundaries of a single sarcomere. The Z disks are the attachment sites for the thin filaments. Therefore, from each Z disk, thin filaments extend to two neighboring sarcomeres.
The Role of Z-disc Proteins in Myopathy and Cardiomyopathy
Mar 17, 2021 · This review will focus on six key Z-disc proteins: α-actinin 2, filamin C, myopalladin, myotilin, telethonin and Z-disc alternatively spliced PDZ-motif (ZASP), which have all been linked to myopathies and cardiomyopathies.
The vertebrate muscle Z-disc: sarcomere anchor for structure …
Oct 15, 2009 · Comprehensive reviews on the roles of the numerous proteins located at the Z-disc in signalling and disease have been published; the aim here is different, namely to review the advances in structural aspects of the Z-disc.
Structural and signaling proteins in the Z-disk and their role in ...
Mar 2, 2023 · This review discusses the various Z-disk proteins (alpha-actinin, filamin C, titin, muscle LIM protein, telethonin, myopalladin, nebulette, and nexilin) and Z-disk-associated proteins (desmin, and obscurin) and their role in cardiac structural stability and …
The sarcomeric Z-disc: a nodal point in signalling and disease
Jan 17, 2006 · In this review, we provide a systematic view on the currently known Z-disc components and the functional significance of the Z-disc as an interface between biomechanical sensing and signalling in cardiac and skeletal muscle functions and diseases.
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