Roles of XBP1s in Transcriptional Regulation of Target Genes
The spliced Xbp1 mRNA is translated by frameshift into an active transcription factor, XBP1s. Then, XBP1s upregulates the expression of UPR target genes, including ER chaperones, …
Roles of XBP1s in Transcriptional Regulation of Target Genes
Jul 8, 2021 · The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum …
Systemic Delivery of Aptamer-Conjugated XBP1 siRNA …
Jul 2, 2020 · Recently, X-box binding protein 1 (XBP1) has been involved in triple-negative breast cancer (TNBC) chemoresistance and progression, but its function in HER2+ breast cancer is …
XBP1 modulates endoplasmic reticulum and mitochondria
Feb 17, 2023 · In vivo and in vitro, we examined the molecular mechanisms and functions of XBP1-NLRP3 signaling in renal IRI, which influences ER-mitochondrial crosstalk. In this study, …
Targeting X box-binding protein-1 (XBP1) enhances the sensitivity …
Mar 1, 2022 · We revealed the mechanism of XBP1′s protection in osteosarcoma cells may be related to the regulation of oxidation-antioxidant system. Photodynamic therapy (PDT), utilizes …
XBP1 promotes triple-negative breast cancer by controlling …
Mar 23, 2014 · Here we report that XBP1 is activated in TNBC and has a pivotal role in the tumorigenicity and progression of this human breast cancer subtype. In breast cancer cell line …
Unravel the molecular mechanism of XBP1 in regulating the …
A genome-wide siRNA screening has been conducted for a systematic assessment of mediating network that 162 genes have been involved in regulating XBP1 splicing and UPR in breast …
Vascular Endothelial Cell Growth–Activated XBP1 Splicing in …
Mar 25, 2013 · Vascular endothelial cell growth factor plays a pivotal role in angiogenesis via regulating endothelial cell proliferation. The X-box binding protein 1 (XBP1) is believed to be a …
Systemic Delivery of Aptamer-Conjugated XBP1 siRNA ... - PubMed
Jul 22, 2020 · Recently, X-box binding protein 1 (XBP1) has been involved in triple-negative breast cancer (TNBC) chemoresistance and progression, but its function in HER2+ breast …
siRNA-loaded folic acid-modified TPGS alleviate MASH
Jul 8, 2024 · Herein, we formulated an Xbp1 siRNA delivery system based on folic acid modified D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles (FT@XBP1) to explore the …