Wnt-10a is a protein that in humans is encoded by the WNT10A gene. [5][6][7] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

Apr 28, 2003 · Classic HED can be diagnosed after infancy based on physical features in most affected individuals. Identification of a hemizygous EDA pathogenic variant in an affected male or biallelic EDAR, EDARADD, or WNT10A pathogenic variants in an affected male or female confirms the diagnosis.

WNT10A gene mutations account for about 5 percent of all cases of hypohidrotic ectodermal dysplasia. Most of the WNT10A gene mutations associated with hypohidrotic ectodermal dysplasia change single protein building blocks (amino acids) in the WNT10A protein, which impairs its function.

Dec 25, 2024 · WNT10A (Wnt Family Member 10A) is a Protein Coding gene. Diseases associated with WNT10A include Schopf-Schulz-Passarge Syndrome and Odontoonychodermal Dysplasia. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Wnt Pathway.

Jun 7, 2017 · Our data identify WNT10A as a critical ligand controlling adult epithelial proliferation and region-specific differentiation, and suggest downstream β-catenin pathway activation as a potential...

Oct 1, 2019 · WNT10A is a member of the WNT proteins family that is essential for the formation of tissues that arise from the ectoderm, including skin, hair, nails, teeth, and sweat glands. WNT10A is particularly important for the formation and shaping of both baby (primary) teeth and adult (permanent) teeth.

WNT10A is a member of the WNT proteins family that is essential for the formation of tissues that arise from the ectoderm, including skin, hair, nails, teeth, and sweat glands. WNT10A is particularly important for the formation and shaping of both baby (primary) teeth and adult (permanent) teeth.

Feb 8, 2025 · WNT10A acts as an autocrine oncogene both in renal cell carcinoma carcinogenesis and progression by activating WNT/beta-catenin signaling. In a panel of 34 patients with isolated hypodontia, the candidate gene WNT10A and the genes MSX1, PAX9, IRF6 and AXIN2 have been sequenced.

In this review, we detail how WNT10A is implicated as a key physiological and pathological contributor to syndromic and nonsyndromic disorders, as well as population variants, affecting the skin and teeth, and document all reported mutations in WNT10A with …

Nov 27, 2023 · WNT10A variants: following the pattern of inheritance in tooth agenesis and self-reported family history of cancer. Novel Dental Anomaly-associated Mutations in WNT10A Protein Binding Sites. WNT10A induces apoptosis of senescent synovial resident stem cells through Wnt/calcium pathway-mediated HDAC5 phosphorylation in OA joints.