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Results: Norepinephrine increased in vitro BAT activity in adipocytes derived from human BAT, and this increase was abolished by propranolol. Furthermore, in vitro BAT activity showed a negative correlation to age and BMI.

Feb 15, 2024 · In this study, we conduct in vitro and in vivo experiments on seven bat species to investigate their cancer resistance. We find that the big-footed bat, Myotis pilosus, exhibits particularly...

Brown adipocytes are the key cell type in brown adipose tissue (BAT) that express the genes required for heat production through the process of thermogenesis. Brown adipocyte cell culture models are important for researching the molecular pathways that control cell …

Dec 19, 2022 · SARS-CoV-2 replication in bat intestinal organoids further supported that bat organoids served as an in vitro correlate of bat intestinal epithelium for phenocopying viral tropism in bat...

Nov 7, 2023 · Functional human brown and white adipose tissue (BAT and WAT) are vital for thermoregulation and nutritional homeostasis, while obesity and other stressors lead, respectively, to cold intolerance and metabolic disease.

Nov 5, 2024 · Accumulating data suggest that some bat species host emerging viruses that are highly pathogenic in humans and agricultural animals. Laboratory-based studies have highlighted important adaptations in bat immune systems that allow them to better tolerate viral infections compared to humans.

Jul 12, 2016 · These findings that glucocorticoids enhance BAT activity in humans both in vivo and in vitro, most likely by increasing UCP-1, are at odds with consistent previous reports that glucocorticoids suppress BAT activation in rodents.

Oct 26, 2021 · In this study, we screened lactic acid bacteria and bacilli isolated from Nyctalus noctula, Pipistrellus kuhlii, and Eptesicus serotinus bats' feces for oxidative and mutagenic activity in...

1 day ago · In mice, 1 source of brown adipocytes are smooth‐muscle–like cells that express transient receptor potential cation channel subfamily V member 1 (TRPV1). 9 In humans, the mesenchymal fibro‐adipogenic origins of adipocytes have been characterized using scRNA‐seq methodologies in brown adipose tissue (BAT), 10 subcutaneous adipose tissue ...