Oct 27, 2017 · Treatment with vitamin C, a cofactor of α-ketoglutarate and Fe2+-dependent dioxygenases, restores TET enzymatic activity and suppresses leukemia formation (vitamin C …

Jan 14, 2023 · We show that vitamin C reinforces the DNA demethylation cascade, reduces the proportion of hypermethylated loci and diminishes gene expression differences between TET2 …

Sep 17, 2020 · In human AML cells, vitamin C increased TET activity and induced DNA demethylation; gene set enrichment analysis showed that vitamin C-induced genes were …

Jun 30, 2013 · Vitamin C enhances the activity of some Fe (II) 2-oxoglutarate dioxygenases 15, and we therefore reasoned that vitamin C could promote the activity of Tet enzymes, leading …

Jan 14, 2023 · TET2 catalyzes stepwise DNA demethylation in hematopoietic cells. Mutations in the TET2 gene predispose to hematological malignancies by causing DNA methylation …

We show that vitamin C reinforces the DNA demethylation cascade, reduces the proportion of hypermethylated loci and diminishes gene expression differences between TET2 mutation …

Oct 2, 2017 · Vitamin C is an α-KGDD cofactor that has been shown to increase TET catalytic activity, and vitamin C treatment phenocopied Tet2 restoration, suppressing myeloid disease …

Here we report that addition of VitC to ESCs promotes Tet activity leading to a rapid and global increase in hmC. This is followed by DNA demethylation of numerous gene promoters and up …

Nov 2, 2017 · Two new studies in Nature and Cell, from Agathocleous et al. (2017) and Cimmino et al. (2017), respectively, show that vitamin C regulates HSC function and suppresses …

Aug 8, 2013 · Here we report that addition of vitamin C to mouse ES cells promotes Tet activity, leading to a rapid and global increase in 5hmC. This is followed by DNA demethylation of …