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PubMed
https://pubmed.ncbi.nlm.nih.gov
VISTA promotes the metabolism and differentiation of myeloid …
Jan 23, 2024 · We report that the V-domain suppressor of T cell activation (VISTA) functions as a key enabler of MDSC differentiation. VISTA deficiency reduced STAT3 activation and STAT3 …
- VISTA is highly expressed on …
  Here we report that VISTA is highly expressed on myeloid-derived …
- VISTA is highly expressed on …
  Here we report that VISTA is highly expressed on myeloid-derived …
- Hypoxia-Induced VISTA Pro…
  Using chromatin immunoprecipitation and genetic silencing, we show that hypoxia …
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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
VISTA is highly expressed on MDSCs and mediates an inhibition of …
Here we report that VISTA is highly expressed on myeloid-derived suppressor cells (MDSCs) in the peripheral blood of AML patients. Both the frequency and intensity of VISTA expression on …
PubMed
https://pubmed.ncbi.nlm.nih.gov
VISTA is highly expressed on MDSCs and mediates an inhibition
Jul 11, 2018 · Here we report that VISTA is highly expressed on myeloid-derived suppressor cells (MDSCs) in the peripheral blood of AML patients. Both the frequency and intensity of VISTA …
- Author: Liru Wang, Liru Wang, Bei Jia, David F. Claxton, W Christopher Ehmann, Witold B. Rybka, Shin Mineish...
- Publish Year: 2018
Studies of Vista Mdsc
PubMed
VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML
Treatment of acute myeloid leukemia (AML) remains challenging. Enhancement of anti-tumor responses by blocking negative immune regulators is a promising strategy for novel effective leukemia therapeutics. V-domain Ig suppressor of T-cell activation (VISTA) is a recently defined negative regulator me...
Author: Liru Wang
Published: 2018/07/11
Keywords: Acute myel…
PubMed
Hypoxia-Induced VISTA Promotes the Suppressive Function of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
Tumor hypoxia is a negative prognostic factor that is implicated in oncogenic signal activation, immune escape, and resistance to treatment. Identifying the mechanistic role of hypoxia in immune escape and resistance to immune-checkpoint inhibitors may aid the identification of therapeutic targets. ...
Author: Jie Deng
Published: 2019/7
Keywords: National In…
ScienceDirect
VISTA blockade alleviates immunosuppression of MDSCs in oral squamous cell carcinoma
V-domain Ig suppressor of T-cell activation (VISTA) is a novel immune checkpoint regulator that can inhibit T cell-mediated antitumor immunity. Although the use of anti-VISTA monoclonal antibody has demonstrated encouraging outcomes in the therapy of various malignancies, its specific impact and und...
Published: 2023/12/01
Cited By: 0
Keywords: Oral squam…
ScienceDirect
Review article Eliminating a barrier: Aiming at VISTA, reversing MDSC-mediated T cell suppression in the tumor microenvironment
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by producing remarkable clinical outcomes for patients with various cancer types. However, only a subset of patients benefits from immunotherapeutic interventions due to the primary and acquired resistance to ICIs. Myeloid-deri...
Published: 2024/09/15
Keywords: VISTA; MD…
DOI: 10.1016/j.heliyon.…
PubMed
Eliminating a barrier: Aiming at VISTA, reversing MDSC-mediated T cell suppression in the tumor microenvironment
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by producing remarkable clinical outcomes for patients with various cancer types. However, only a subset of patients benefits from immunotherapeutic interventions due to the primary and acquired resistance to ICIs. Myeloid-deri...
Author: Yayuan Deng
Published: 2024/08/30
Keywords: ICIs; Immu…
PubMed
https://pubmed.ncbi.nlm.nih.gov
Hypoxia-Induced VISTA Promotes the Suppressive Function of …
Using chromatin immunoprecipitation and genetic silencing, we show that hypoxia-inducible factor (HIF)-1α binding to a conserved hypoxia response element in the VISTA promoter upregulated …
- Author: Jie Deng, Jiannan Li, Aurelien Sarde, J Louise Lines, Yu-Chi Lee, David C Qian, Dov A Pechenick, Ric...
- Publish Year: 2019
Cell Press
https://www.cell.com › heliyon › fulltext
Eliminating a barrier: Aiming at VISTA, reversing MDSC ... - Cell Press
Sep 15, 2024 · The immunosuppressive ability of MDSC may be impaired by VISTA depletion in three ways: 1) by hindering the infiltration of immature myeloid progenitor cells; 2) by stopping …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Clinical and research updates on the VISTA immune checkpoint: …
In preclinical models, high levels of VISTA expression are found on tumor-infiltrating leukocytes and myeloid-derived suppressor cells (MDSCs) (1, 6, 15 – 17). VISTA expression levels have …
People also ask
Is Vista expressed on myeloid-derived suppressor cells (MDSCs) in AML?
Here we report that VISTA is highly expressed on myeloid-derived suppressor cells (MDSCs) in the peripheral blood of AML patients. Both the frequency and intensity of VISTA expression on MDSCs are significantly higher in newly diagnosed AML than in healthy controls.
VISTA is highly expressed on MDSCs and mediates an
pubmed.ncbi.nlm.nih.gov
Can Vista block MDSCs in patients with OSCC?
Therefore, the inhibition of MDSCs on effector T cells could potentially be suppressed by blocking VISTA, thus presenting a promising therapeutic strategy to enhance the efficacy of ICB in patients with OSCC.
VISTA blockade alleviates immunosuppression of MDSCs in oral squam…
sciencedirect.com
Does Vista blockade reduce MDSCs and boosted CD8+ T cell mediated antitumor effect?
VISTA blockade reduced MDSCs and boosted CD8 + T cell mediated antitumor effect. T RM are the main subsets that increases after VISTA blockade. V-domain Ig suppressor of T-cell activation (VISTA) is a novel immune checkpoint regulator that can inhibit T cell-mediated antitumor immunity.
VISTA blockade alleviates immunosuppression of MDSCs in oral squam…
sciencedirect.com
Does Vista play a role in cancer?
Given its role in the regulation of the immune system, the expression and functions of VISTA in cancers are currently under active investigation. In preclinical models, high levels of VISTA expression are found on tumor-infiltrating leukocytes and myeloid-derived suppressor cells (MDSCs) (1, 6, 15 – 17).
Clinical and research updates on the VISTA immune checkpoint: immuno
pmc.ncbi.nlm.nih.gov
Does Vista blockade treatment affect the infiltration of MDSCs?
This suggests that VISTA blockade treatment has a notable impact on the infiltration of tumors and immunosuppressive functions of MDSCs.
VISTA blockade alleviates immunosuppression of MDSCs in oral squam…
sciencedirect.com
Can Avista reduce the suppressive impact of MDSCs on T cell activation?
Furthermore, MDSCs, a subset of immunosuppressive cells derived from bone marrow cells, have been shown to facilitate the growth of myeloid-like cancer cells while suppressing activated T cells. We postulate that aVISTA could alleviate the suppressive impact of MDSCs on T cell activation.
VISTA blockade alleviates immunosuppression of MDSCs in oral squam…
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Taylor & Francis Online
https://www.tandfonline.com › doi › full
Full article: VISTA is highly expressed on MDSCs and …
Jul 11, 2018 · Patients with newly diagnosed AML display increased expression of VISTA on MDSCs, and VISTA is critical for the MDSC-mediated CD8 T cell response. Importantly VISTA expression is positively associated with T cell …
The Journal for ImmunoTherapy of Cancer
https://jitc.bmj.com › content
971 VISTA regulates the differentiation and function of myeloid …
Mechanistically, VISTA directly controls the signaling of monocytes in response to inflammatory stimuli including GM-CSF and IL-6. Conclusions Our studies uncover VISTA as an important …
The Journal for ImmunoTherapy of Cancer
https://jitc.bmj.com › content
935 VISTA regulates the differentiation of myeloid-derived …
Mechanistically, VISTA directly regulates the signaling of MDSC in response to inflammatory stimuli including GM-CSF and IL-6 by augmenting the activation of STAT3. Phosphorylated …
ScienceDirect
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VISTA blockade alleviates immunosuppression of MDSCs in oral …
Dec 1, 2023 · VISTA blockade boosts the infiltration of T RM and inhibits the MDSCs in 4MOSC2-bearing mouse. Representative immunohistochemistry staining and quantification of VISTA …
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