Vascular endothelial growth factor A (VEGF-A) is a dimeric glycoprotein that plays a significant role in neurons and is considered to be the main, dominant inducer of the growth of blood vessels. VEGFA is essential for adults during organ remodeling and diseases that involve blood vessels, for example, in wound healing, tumor angiogenesis ...

血管内皮生长因子（vascular endothelial growth factor，VEGF），又称血管通透因子（vascular permeability factor，VPF）是一种高度特异性的促血管内皮细胞生长因子，具有促进血管通透性增加、细胞外基质变性、血管内皮细胞迁移、增殖和血管形成等作用。

血管内皮生长因子 A (VEGFA) 是一种高度保守的 27 kDa 二聚体糖蛋白，与 VEGFB、VEGFC、VEGFD 和胎盘生长因子 (PIGF) 同属 VEGF 家族1。 因可变剪接产生的常见亚型有 VEGFA121、VEGFA165、VEGFA189 和 VEGFA206，分别含有 121、165、189 和 206 个氨基酸2。 VEGFA 由内皮细胞以及肿瘤等多种细胞分泌，其最初被证明是一种内皮生长因子以及血管通透性的调节因子 3, 4。 由于 VEGFA 是实体瘤生长过程中血管生成的关键性调节因子，靶向 VEGFA 的治疗 …

VEGF家族蛋白基因结构复杂，其中研究最多的为VEGF-A蛋白。 VEGF-A基因转录形成的前体mRNA 通过可变剪接，可形成不同片段的VEGF-A 蛋白，分别为VEGF121、VEGF145、VEGF165、VEGF110、VEGF183、VEGF189和VEGF209等。 所有的VEGF-A亚型都有一个共同的区域，由第2-5号外显子编码。 第6、7外显子为硫酸肝素糖蛋白 (Heparin sulfate proteoglycans, HSPG)的结合位点，第8号外显子可调节内皮细胞的增殖。 表达最多的VEGF-A亚型 …

Vascular endothelial growth factor (VEGF) represents a growth factor with important pro-angiogenic activity, having a mitogenic and an anti-apoptotic effect on endothelial cells, increasing the vascular permeability, promoting cell migration, etc. Due to these effects, it …

VEGF-A regulates angiogenesis and vascular permeability by activating 2 receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk1 in mice). On the other hand, VEGF-C/VEGF-D and their receptor, VEGFR-3 (Flt-4), mainly regulate lymphangiogenesis.

In vitro, VEGF-A has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF-A is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor. There are multiple isoforms of VEGF-A that result from alternative splicing of mRNA from a single, 8- exon VEGFA gene.

Jun 21, 2021 · 血管内皮生长因子（vascular endothelial growth factor，VEGF），又称血管通透因子（vascular permeability factor，VPF）是一种高度特异性的促血管内皮细胞生长因子，具有促进血管通透性增加、细胞外基质变性、血管内皮细胞迁移、增殖和血管形成等作用。

Jul 25, 2023 · Among these, vascular endothelial growth factor A (VEGFA; also known as VEGF) and its two tyrosine kinase receptors, VEGFR1 and VEGFR2, represent a key...

The vascular endothelial growth factor A (VEGF-A) is the main factor responsible for endothelial cell migration, proliferation and tube formation, and other VEGF family members and their receptors play important roles in vasculogenesis and angiogenesis [3,4,5].