Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. [5] VCAM-1 functions as a cell adhesion molecule.

VCAM-1 is a key cell adhesion molecule involved in inflammation that is closely implicated in various immunological disorders, including rheumatoid arthritis, asthma, transplant rejection, and cancer . VCAM-1 is a potential therapeutic target in immunological disorders and cancer.

Aug 1, 2023 · Intercellular adhesion molecule 1 (ICAM-1) and Vascular cell adhesion molecule 1 (VCAM-1) belong to the immunoglobulin superfamily of cell adhesion molecules (CAM) with a crucial role in mediating the strong adherence of leukocytes to endothelial cells in numerous acute as well as chronic diseases.

Dec 25, 2024 · Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include integrin binding and primary methylamine oxidase activity .

The vascular cell adhesion molecule VCAM-1 was originally identified as a cytokine-inducible adhesion molecule on human endothelial cells, mediating the binding to leukocytes and melanoma cells (178,203,204). VCAM-1 is a ligand for the α4β1 integrin (VLA-4) and binds weakly to α4β7 (102,205–207).

Aug 1, 2023 · VCAM-1 and ICAM-1 are integral membrane proteins that are broadly dispersed in an adult brain and have an impact on neurons, astrocytes, microglial cells, and cerebral vascular endothelial cells. Research clearly shows that VCAM-1 …

Sep 1, 2021 · The vascular cellular adhesion molecule-1 (VCAM-1) is a protein that canonically participates in the adhesion and transmigration of leukocytes to the interstitium during inflammation.

E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1) were measured in serum from hypertensive patients with LV hypertrophy Strongly expressed in histological type II of rheumatoid arthritis.

Recent studies have shown that vascular cell adhesion molecule-1 (VCAM-1) is aberrantly expressed in breast cancer cells and mediates pro-metastatic tumor-stromal interactions. Moreover, the usefulness of VCAM-1 to DTCs in two different organs –lung and bone– is based on distinct mechanisms.

There is emerging evidence that VCAM-1 is more than a biomarker and may be a promising therapeutic target for vascular diseases. While there are neutralizing antibodies that allow preclinical research, the development of pharmacological tools to activate or inhibit this protein are required to thoro …