Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene. [5] Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are …

Dec 25, 2024 · TUBA4A (Tubulin Alpha 4a) is a Protein Coding gene. Diseases associated with TUBA4A include Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia …

Jul 20, 2022 · We found that Tuba4a lacking C-terminal polyglutamylation prevents the binding of Tau and GSK3 kinase to neuronal microtubules, thereby strongly reducing phospho-Tau levels.

Feb 9, 2025 · Tandem affinity purification and mass spectrometry analysis identify tubulin alpha 4a protein (TUBA4A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP …

Feb 6, 2023 · The recent linkage of mutations to the tubulin α chain, TUBA4A, to familial and sporadic cases of ALS provides a new investigative opportunity to shed light on both …

Feb 27, 2020 · A potential role for detyrosination in regulating microtubule flexibility can be inferred from the role of a specific α-tubulin isotype, α4A-tubulin (encoded TUBA4A).

The frequency of TUBA4A mutations suggests that TUBA4A is a rare cause of Amotrophic Lateral Sclerosis in Chinese patients. Data indicate a microRNA-1825/TBCB/TUBA4A pathway as a …

Apr 7, 2024 · Clinical resource with information about TUBA4A, Amyotrophic lateral sclerosis type 22, Many sequence variants affecting diversity of adult human height., and available tests. …

Aug 23, 2023 · We identified three isolated patients with heterozygous variants in the TUBA4A gene (Fig. 1A). The proband in Trio 1 carried a c.850G > A;p.E284K variant, which was …

Apr 18, 2022 · Smith et al. (2014) also investigated the ability of mutant TUBA4A to efficiently form microtubules using a cell-free system to quantify its incorporation into alpha/beta-tubulin …