TrkA is the high affinity catalytic receptor for the neurotrophin, Nerve Growth Factor, or "NGF". As a kinase, TrkA mediates the multiple effects of NGF, which include neuronal differentiation , …

Target-derived neurotrophin nerve growth factor (NGF) and its receptor TrkA are well known for retrograde signaling to promote survival and innervation of sympathetic and sensory neurons.

The TrkA receptor is a neurotrophin-binding tyrosine kinase receptor that plays a crucial role in signal transduction and cellular responses to nerve growth factor (NGF) and other neurotrophins.

Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system. [1][2] Trk receptors affect neuronal survival and differentiation …

Sep 6, 2016 · Here, we show that nerve growth factor (NGF) signaling through neurotrophic tyrosine kinase receptor type 1 (TrkA) directs innervation of the developing mouse femur to …

Mar 4, 2023 · Proper wiring of the peripheral nervous system relies on neurotrophic signaling via nerve growth factor (NGF). NGF secreted by target organs (i.e. eye) binds to the TrkA receptor …

Using compound mice carrying mutant TrkA alleles and sensitive fluorescent sensory nerve reporters, we demonstrate that TrkA signaling is required for sensory nerve regeneration and …

Bone is richly innervated by nerve growth factor–responsive (NGF-responsive) tropomyosin receptor kinase A–expressing (TrKa-expressing) sensory nerve fibers, which are required for …

Jun 20, 2024 · TrkA inhibition in transgenic mice led to significant reductions in sarcoma-associated sensory innervation and vascularization, tumor growth and metastasis, and …

Aug 16, 2021 · Having identified the central role of NGF, we next set to validate that NGF exerts its effects on nerve ingrowth and secondarily stem cell fate decisions via its high-affinity …