May 8, 2019 · Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL/TNFSF10) and Fas Ligand (FasL/TNFSF6), two major cytokines of the TNF (Tumor Necrosis Factor) …

Mar 1, 2015 · Fas (CD95) and TRAIL are the most intensively studied members of the death receptor family and how engagement of these cell surface receptors initiate apoptosis is now …

TRAIL was discovered by comparing the sequence of its c-terminal (CTE) domain to that of other TNF superfamily members, such as FasL and TNF-α [1,2]. Since then, TRAIL has been shown …

May 8, 2019 · This review summarizes the state of current knowledge regarding the key death and non-death immune functions that TRAIL and FasL play in the initiation and progression of …

Here, we present a protocol for immunoprecipitation of TRAIL- or Fas-induced FADDosomes from human cell lines. We describe steps for stimulating human cells with TRAIL or Fas ligand, …

Apr 22, 2010 · To delineate the relative roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas ligand in lymphocyte biology and lymphoproliferative disease, we …

Dec 26, 2023 · cFLIP is well known to suppress apoptosis initiated through engagement of Fas, TRAIL, or tumor necrosis factor (TNF) “death receptors.” Davidovich et al. show that cFLIP …

Sep 1, 1998 · In the present study, we have tested melanoma cells for their susceptibility to apoptosis induced by human TNF-related apoptosis-inducing ligand (TRAIL) and the ability of …

Sep 13, 2001 · FasL and TNF-related apoptosis-inducing ligand (TRAIL) belong to a subgroup of the TNF superfamily which induce apoptosis by binding to their death domain containing …

Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors (TRAILR1 and TRAILR2) are promising targets for cancer therapy: both recombinant TRAIL and monoclonal …