TAp63-mediated senescence overrides Ras-driven transformation of p53-deficient cells, preventing tumour initiation, and doxycycline-regulated expression of TAp63 activates p21 Waf/Cip1, induces senescence and inhibits progression of established tumours in vivo.

Apr 1, 2013 · We found that like downregulation of p53, downregulation of p63 and TAp63 decreases expression of growth-suppressing genes, including p21, PUMA and MIC-1, and consequently promotes cell...

All isoforms of TAp63 transactivate the p21-encoding gene, with TAp63β showing the highest levels of p21 induction (Helton et al., 2008). The transcriptional activation of p21 by TAp63 requires both the AD and proline-rich domains of TAp63.

We found that downregulation of p53, p63 and TAp63 decreases the expression of growth-suppressing genes, including p21, PUMA and MIC-1. Interestingly, downregulation of p63, particularly TAp63, but not p53, disrupts the ability of MDCK cells to form a cyst structure in 3-D culture via heightened epithelial-to-mesenchymal transition (EMT).

Sep 11, 2020 · All isoforms of TAp63 transactivate the p21-encoding gene, with TAp63β showing the highest levels of p21 induction (Helton et al., 2008). The transcriptional activation of p21 by TAp63 requires both the AD and proline-rich domains of TAp63.

Here we show that TAp63 isoforms are robust mediators of senescence that inhibit tumorigenesis in vivo. Whereas gain of TAp63 induces senescence, loss of p63 enhances sarcoma development in...

We observed that down-regulation of ΔNp63 or all p63 isoforms, but not TAp63, led to substantial cellular senescence, associated with increased expression of p21 and lack of induction of p16. This result suggests that down-regulation of p63 or ΔNp63 in cells led to increased senescence.

Nov 28, 2018 · p53, with its family members p63 and p73, have been shown to promote myoblast differentiation by regulation of the function of the retinoblastoma protein and by direct activation of p21 Cip/Waf1 and p57 Kip2, promoting cell cycle exit.

Nov 8, 2009 · TAp63-mediated senescence overrides Ras-driven transformation of p53-deficient cells, preventing tumour initiation, and doxycycline-regulated expression of TAp63 activates p21 Waf/Cip1,...

SCF TrCP1 is able to bind p63 isoforms, with a higher affinity for the TAp63 isoform. Strikingly, co-expres-sion of TAp63 and TrCP1 leads to the stabilization of TAp63 . This stabilization of TAp63 leads to up-regulation of p21 at the mRNA and protein level by increased binding of TAp63 at the p21 promoter. The up-regulation of p21 causes a.